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KMID : 0360419760120010063
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Korean Journal of Pharmacology
1976 Volume.12 No. 1 p.63 ~ p.67
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Effect of Ginseng on the acquisition ofconditioned avoidance response in rats
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Abstract
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The purpose of the present study was to see the Panax Ginseng has any influence upon the acquisition of the conditioned avoidance response(CAR) in rats.
Sixty male rats of Holtzman strain were used. The animal weighed between 20 and 300 gm at the beginning of the experiment. Training of avoidance conditioning was done in a two-way shuttle box which was separated into two compartments by a guilotine door. The conditioned stimulus (CS) was a light beam and the unconditioned stimulus (UCS) was an electric shock. The shock was presented 10 sec. after onset of the CS and continued until the subject crossed to the opposite safety compartment within 20 sec. after onset of UCS. Each S was received 30 trials a day (one session) for 6 consecutive sessions. The number of CR which avoided successfuly without having shock and the number of fecal balls during the conditioning were served as an index of learning performance and emotionality.
The results obtained as follows.
All doses of Ginseng saponin treated animals showed more CR than control, but did not differ significantly from control.
Ginseng saponin treated animals with the doses of 50~100 mg/kg defecated the fecal balls significantly less frequent than the placebo control during CAR.
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